Michael Poirier

Assistant Professor

Department of Physics

The Ohio State University

I am a member of the Biophysics Graduate Program and

the Ohio State Biochemistry Program.

my curriculum vitae

Physics 111 Course Information

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Contact information:

2140 Physics Research Building
191 West Woodruff Avenue
Columbus, Ohio 43210-1117
email: mpoirier@mps.ohio-state.edu
Office: Rm 2140 PRB, Phone, (614) 247-4493
Lab: Rm 2135 & 2147 PRB, Phone: (614)  688-0742
Fax: (614) 292-7557

Biological Physics Research

Chromatin Structure and Function


Chromosome Dynamics


 

Lab Members:

Robin Nakkula, Research Associate

Marek Simon, Physics Grad. Student
 
Justin North, Physics Grad. Student
 
Robert Fortes, Physics Grad. Student

Liana Bonanna, Physics Undergrad. Student


Publications

Current PubMed listing


Poirier MG, Bussiek M, Langowski J and Widom J (2007) Spontaneous access to DNA target sites in folded chromatin fibers, Submitted to JMB

Poirier, M.G. and Marko, J.F. Micromechanical studies of mitotic chromosomes (Review). (2003) Curr Top Dev Biol. 55:75-141.


Poirier, M.G. and Marko, J.F. Micromechanics of chromatin and chromosomes (Review). (2003) Biochem Cell Biol. Jun;81(3):209-20.


Poirier, M.G. and Marko, J.F. Micromechanical properties of mitotic chromosomes (Review). (2003) J Musc Res Cell Motil. 23, 409-431.


Poirier, M.G. and Marko, J.F. Mitotic chromosomes are chromatin networks without an internal protein scaffold. (2002) Proc Natl Acad Sci USA 99, 15393-15397.


Commentary by A.S. Belmont
Mitotic chromosome scaffold structure: New approaches to an old controversy Proc. Natl. Acad. Sci. USA 99, 15855-7 (2002)


Sarkar, A., Eroglu, S., Poirier, M.G., Nemani, A., Gupta, P. and Marko, J.F. Dynamics of Chromosome Compaction During Mitosis, Exp Cell Res. (2002) Jul 1;277(1):48-56.


Poirier, M.G. and Marko, J.F. Effect of Internal Friction on Biofilament Dynamics (2002) Phys Rev Lett. 88(22):228103.


Poirier, M.G., Eroglu, S. and Marko, J.F. The bending rigidity of mitotic chromosomes (2002)


Poirier, M.G., Monhait, T. and Marko, J.F. Reversible hypercondensation and decondensation of mitotic chromosomes studied using combined chemical-micromechanical techniques. (2002) J Cell Biochem. 85:422-424.


Poirier, M.G., Nemani, A., Gupta, P., Eroglu, S. and Marko, J.F. Probing chromosome structure with dynamic force relaxation (2001) Phys Rev Lett. 86, 360-363.


Poirier, M. Eroglu, S., Chatenay, D. and Marko, J.F. Reversible and irreversible unfolding of mitotic newt chromosomes by applied force (2000) Mol Biol Cell 11, 269-276.

Micromechanical-Biochemical Studies of Mitotic Chromosome Structure
My Ph.D. Thesis, University of Illinois at Chicago (2001)
(Note that sections of this thesis have been separately published as research papers)

External Funding

I am grateful to the Burroughs Wellcome Fund, the National Institute of General Medical Sciences at the National Institutes of Health and The Ohio State University for their support of my group's research .