Recent progress on isospin symmetry breaking in hadrons is presented. Results from our first study of Nf=2+1 QCD+QED calculation using chiral lattice quark, domain-wall fermions, are reported , which include determination of up, down strange quark masses, two origins of isospin breaking, correction to Dashen's theorem and the neutron-proton mass splittings. Related recent works [2,3] are also briefly mentioned along with the main content of the talk.
 T. Blum, R. Zhou, T. Doi, M. Hayakawa, T. Izubuchi, S. Uno, (Nagoya U.) , N. Yamada, "Electromagnetic mass splittings of the low lying hadrons and quark masses from 2+1 flavor lattice QCD+QED" arXiv:1006.1311 [hep-lat]
 N.H. Christ, C. Dawson, T. Izubuchi, C. Jung, Q. Liu, R.D. Mawhinney, C.T. Sachrajda, A. Soni, R. Zhou, "The $\eta$ and $\eta^\prime$ mesons from Lattice QCD" arXiv:1002.2999 [hep-lat]
 Y. Aoki et al. [ RBC and UKQCD collaboration ] "Continuum Limit Physics from 2+1 Flavor Domain Wall QCD" arXiv:1011.0892 [hep-lat]